The inhibition of type I bacterial signal peptidase: Biological consequences and therapeutic potential

A. Craney, F.E. Romesberg, Bioorg. Med. Chem. Lett. (2015) 25:4761–4766.
pubpic2015xxWe review the information gained from the use of SPase inhibitors as probes of prokaryote biology. A thorough understanding of the consequences of SPase inhibition and the mechanisms of resistance that arise are essential to the success of SPase as an antibiotic target. In addition to the role of SPase in processing secreted proteins, the use of SPase inhibitors has elucidated a previously unknown function for SPase in regulating cleavage events of membrane proteins.