Origins of Y. pestis sensitivity to the arylomycin antibiotics and the inhibition of type I signal peptidase

D.B. Steed, J. Liu, E. Wasbrough, L. Miller, S. Halasohoris, J. Miller, B. Somerville, J.R. Hershfield, F.E. Romesberg, Antimicrob. Agents Chemother. (2015) 59:3887-3898.
pubpic2015steedWe demonstrate that arylomycin activity is conserved against a broad range of Y. pestis strains and that this activity results from SPase inhibition. The origins of the sensitivity are traced to an increased dependence on SPase that results from high levels of protein secretion under physiological conditions.