A putative Cro-like repressor contributes to arylomycin resistance in Staphylococcus aureus

A. Craney, F.E. Romesberg, Antimicrob. Agents Chemother. (2015) 59:3066-3074.
pubpic201craneyWe characterized the susceptibility of a panel of S. aureus strains to two arylomycin derivatives and observed a wide range of susceptibilities. We found that resistant strains were sensitized by co-treatment with tunicamycin, which inhibits the first step of wall teichoic acid synthesis. Transcriptional profiling using growth inhibitory concentrations of arylomycin revealed further insight into how this pathogen copes with secretion stress.