Efforts toward broadening the spectrum of arylomycin antibiotic activity

J. Liu, P.A. Smith, D.B. Steed, F.E. Romesberg, Bioorg. Med. Chem. Lett., (2013) 23:5654-5659.
pubpic201liuWe report the synthesis and evaluation of several arylomycin derivatives, and demonstrate that both C-terminal homologation with a glycyl aldehyde and addition of a positive charge to the macrocycle increase the activity and spectrum of the arylomycin scaffold.