KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry

K. Betz, D.A. Malyshev, T. Lavergne, W. Welte, K. Diederichs, T.J. Dwyer, P. Ordoukhanian, F.E. Romesberg, A. Marx, Nat. Chem. Biol. (2012) 8:612-614.
pubpic2012betzWe report crystal structures of KlenTaq DNA polymerase at different stages of replicating dNaM-d5SICS, and show that efficient replication results from the polymerase itself inducing the required natural-like structure. Read more in Live Science.