Type I signal peptidase and protein secretion in S. aureus

M.A. Schallenberger, S. Niessen, C. Shao, B.J. Fowler, F.E. Romesberg, J. Bacteriol. (2012) 194:2677-2686.
pubpic2012schallenbergerWe use an arylomycin as a probe of protein secretion to identify forty-six proteins whose extracellular accumulation in S. aureus requires the activity of signal peptidase (SPase). These include a wide variety of virulence proteins with identifiable Sec-type signal peptides, as well as some proteins with non-canonical cleavage sites.