Synthesis and biological characterization of arylomycin B antibiotics

T.C. Roberts, P.A. Smith, F.E. Romesberg, J. Nat. Prod. (2011) 74:956-961.
pubpic2011robertsWe report the total synthesis of arylomycin B-C16, and its aromatic amine derivative. While the aromatic amine loses activity against all bacteria tested, the B series compound shows activities that are similar to the A series compounds, except that it also gains activity against the important pathogen Streptococcus agalactiae.