Broad spectrum antibiotic activity of the arylomycin natural products is masked by natural target mutations

P.A. Smith, T.C. Roberts, F.E. Romesberg, Chem. Biol. (2010) 17:1223-1231.
pubpic2010smithWe demonstrates that the apparently narrow spectrum of the arylomycin natural products results not from intrinsic limitations, but from target mutations and that the arylomycins have a much broader spectrum of activity than previously thought.

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