The psychotrimine natural products have antibacterial activity against Gram-positive bacteria and act via membrane disruption

M.A. Schallenberger, T. Newhouse, P.S. Baran, F.E. Romesberg, J. Antibiot. (2010) 63:685-687.
pubpic2010schallenbergerPlants provide a unique source of diverse secondary metabolites with potentially important biological activities, with one of the most promising classes being the indole alkaloids. One such indole alkaloid natural product is psychotrimine, which has attracted considerable interest from the synthetic and medicinal chemistry communities owing to its unusual connectivity between tryptamine subunits. Here, we examine the potential antibacterial activity of this unique indole alkaloid.