Secretion of the chlamydial virulence factor CPAF requires Sec-dependent pathway

D. Chen, L. Lei, C. Lu, R. Flores, M.P. DeLisa, T.C. Roberts, F.E. Romesberg, G. Zhong, Microbiology (2010) 156:3031-3040.
pubpic2010chenCPAF is secreted into host cytosol to degrade various host factors for benefiting chlamydial intracellular survival. Here, we show experimental evidence that the chlamydial virulence factor CPAF relies on sec-dependent transport for crossing the chlamydial organism inner membrane.