PCR with an expanded genetic alphabet

D. Malyshev, Y.J. Seo, P. Ordoukhanian, F.E. Romesberg, J. Am. Chem. Soc. (2009) 131:14620-14621.
pubpic2009malyshevWe demonstrate that DNA containing either the d5SICS−dNaM or d55SICS−dMMO2 unnatural base pair may be amplified by PCR with fidelities and efficiencies that approach those of fully natural DNA.

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