C-D Modes of deuterated side chain of leucine as structural reporters via dual-frequency two-dimensional infrared spectroscopy

S.R.G. Naraharisetty, V.M. Kasyanenko, J. Zimmermann, M.C. Thielges, F.E. Romesberg, I.V. Rubtsov, J. Phys. Chem. B, (2009) 113:4940-4946.
pubpic2009naraharisettyWe demonstrate that the C-D transitions of the deuterated amino acid, leucine-d10 can serve as convenient structural reporters via dual-frequency 2DIR methods, and we discuss the potential of leucine-d10 and other amino acids with deuterium-labeled side chains as probes of protein structure and dynamics.