Identification of pathways controlling DNA damage induced mutation in Saccharomyces cerevisiae

E.T. Lis, B.M. O’Neill, C. Gil-Lemaignere, J.K. Chin, F.E. Romesberg, DNA Repair (2008) 7:801-810.
pubpic2008lisTo further understand the mutagenic response to DNA damage, we screen a collection of 4848 haploid gene deletion strains of S. cerevisiae for decreased damage-induced mutation of the CAN1 gene, and we identify a pathway of induced mutation that involves a replicative polymerase and that is effectively inhibited by the RNR inhibitor, hydroxyurea.