Structural and initial biological analysis of synthetic arylomycin A2

T.C. Roberts, P.A. Smith, R.T. Cirz, F.E. Romesberg, J. Am. Chem. Soc. (2007) 129:15830-15838.
pubpic2007robertsWe report the synthesis and characterization of arylomycin natural products. These studies help identify the determinants of the biological activity of arylomycin A2 and should aid in the design of analogs to further explore and develop this novel class of antibiotic.

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