Controlling mutation: intervening in evolution as a therapeutic strategy

R.T. Cirz and F.E. Romesberg, Crit. Rev. Biochem. Mol. Biol. (2007) 42:341-354.
pubpic2007cirzWe review what is known about induced mutagenesis in bacteria as well as evidence that it contributes to the evolution of antibiotic resistance and we discuss the possibility that components of induced mutation pathways might be targeted for inhibition as a novel therapeutic strategy to prevent the evolution of antibiotic resistance.