Combating bacteria and drug-resistance by inhibiting mechanisms of persistence and adaptation

P.A. Smith and F.E. Romesberg, Nat. Chem. Biol. (2007) 3:549-556.
pubpic2007smithAn improved understanding of bacterial stress responses and evolution suggests that in the ability of bacteria to survive antibiotic therapy either by transiently tolerating antibiotics or by evolving resistance may require specific biochemical processes. We review early efforts toward inhibiting these processes as a means to prolong the efficacy of current antibiotics and provide an alternative to escalating the current arms race between antibiotics and bacterial resistance.