Efforts towards expansion of the genetic alphabet: pyridone and methyl pyridone nucleobases

A.M. Leconte, S. Matsuda, G.T. Hwang, F.E. Romesberg. Angew. Chem. Int. Ed. (2006) 45:4326-4329.
We report the synthesis and characterization of nucleotides bearing pyridone nucleobase analogues, which are expected to position their carbonyl group into the minor groove.