Redox-coupled dynamics and folding in cytochrome c

L.B. Sagle, J. Zimmermann, S. Matsuda, P.E. Dawson, F.E. Romesberg, J. Am. Chem. Soc. (2006) 128:7909-7915.
pubpic2005xxWe incorporated carbon−deuterium bonds throughout cyt c and characterized their absorption frequencies and line widths using IR spectroscopy. Our data suggest that while the oxidized protein is not more flexible than the reduced protein, it is more locally unfolded..

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