An efficiently extended class of unnatural base pairs

A.M. Leconte, S.Matsuda, F.E.Romesberg, J. Am. Chem. Soc. (Comm.) (2006) 128:6780-6781.
pubpic2006leconteWe describe a simple screen that enables the characterization of large numbers of previously uncharacterized hetero base pairs. From this screen, we identify a class of unnatural base pairs which are extended more efficiently than any unnatural base pair reported to date.