Efforts toward developing direct probes of protein dynamics

M.E. Cremeens, H. Fujisaki, Y. Zhang, J. Zimmermann, L.B. Sagle, S. Matsuda, P.E. Dawson, J.E. Straub, F.E. Romesberg, J. Am. Chem. Soc. (Comm.) (2006) 128(18):6028-6029.
pubpic2006cremeensWe report the first IR characterization of a single C−D bond within a protein, methyl-d1 Met80 of horse heart cytochrome c. A comparison was made to methyl-d1/d3 methionine as well as methyl-d3 Met80.