Esc4/Rtt107 and the control of recombination during replication

J.K. Chin, V.I. Bashkirov, W.-D. Heyer, F.E. Romesberg, DNA Repair (2006) 5:618-628.
pubpic2006chinWe show that Esc4 interacts with several proteins involved in the repair and processing of stalled or collapsed replication forks, including the recombination protein Rad55, and we propose that Esc4 associates with ssDNA of stalled forks and acts as a scaffolding protein to recruit and/or modulate the function of other proteins required to reinitiate DNA synthesis.