Polymerase evolution: efforts toward expansion of the genetic code

A.M. Leconte, L.Chen, F.E. Romesberg, J. Am. Chem. Soc. (Comm.) (2005) 127:12470-12471.
pubpic2005leconteWe report the use of an activity-based selection system to evolve a DNA polymerase that more efficiently replicates DNA containing the PICS self-pair.

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