Isotope effects and quantum tunneling in enzyme-catalyzed hydrogen transfer. Part I. The experimental basis
F.E. Romesberg, R.L. Schowen, Adv. Phys. Org. Chem. (2004) 39:27–77.
We review the role of quantum tunneling as a mechanism of the enymatic transfer of hydrogenic entities (protons, hydrogen atoms, and hydride ions), including the background of the subject, the conceptual apparatus that underlies the isotopic studies, the phenomenology of the experimental observations, and a qualitative sketch of the interpretative, mechanistic models that have emerged.