Flexibility and molecular recognition in the immune system

R. Jimenez, G. Salazar, K.K. Baldridge, F.E. Romesberg, Proc. Natl. Acad. Sci. USA (2003) 100:92–97.
pubpic2003jimenezWe use photon echo spectroscopy to measure the response of three antibody-binding sites to perturbation from electronic excitation of a bound antigen, fluorescein. The three antibodies show motions that range in time scale from tens of femtoseconds to nanoseconds. This work was featured on the cover.