Polymerase recognition of unnatural base pairs

C. Yu, A.A. Henry, F.E. Romesberg, P.G. Schultz, Angew. Chem. Int. Ed. Engl. (2002) 41:3841-3844.
pubpic2002yuHeteroatom substitution of ICS via replacement of C6 with nitrogen and thio substitution at C10 provides the base SNICS, which forms stable self-pairs and can therefore be used for efficient unnatural base pair replication.