Efforts toward expansion of the genetic alphabet: replication of DNA with three base pairs

E.L. Tae, Y. Wu, G. Xia, P.G. Schultz, F.E. Romesberg, J. Am. Chem. Soc. (Comm.) (2001) 123:7439-7440.
pubpic2001taeWe show that the unnatural self-pair formed between two 7-azaindole nucleosides can be replicated in DNA using binary polymerase system – KF efficiently synthesizes the self-pair, and pol β efficiently extends it.

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