A Novel Copper-Mediated DNA Base Pair

E. Meggers, P.L. Holland, W.B. Tolman, F.E. Romesberg, P.G. Schultz, J. Am. Chem. Soc. (Comm.) (2000) 122:10714–10715.
pubpic2000meggersWe describe a base pair with a pyridine-2,6-dicarboxylate nucleobase (Dipic) as a planar tridentate ligand, and a pyridine nucleobase (Py) as the complementary single donor ligand. Characterization of this base pair in duplex DNA shows that interbase metal coordination can replace the hydrogen bonding schemes found in the natural base pairs dA:dT and dG:dC.