Rational design of an unnatural base pair with increased kinetic selectivity

A.K. Ogawa, Y. Wu, M. Berger, P.G. Schultz, F.E. Romesberg, J. Am. Chem. Soc. (Comm.) (2000) 122:8803-8804.

pubpic2000bogawaHere we report the synthesis and characterization of 3MN and 2Np, and we show that the 3MN:3MN self-pair is synthesized by KF with an efficiency of 2.4 × 106 M-1min-1.