Stable and selective hybridization of oligonucleotides with unnatural hydrophobic bases

M. Berger, A.K. Ogawa, D.L. McMinn, Y. Wu, P.G. Schultz, F.E. Romesberg, Angew. Chem. Int. Ed. Engl. (2000) 39:2940-2942.
pubpic2000bergerRelying on only interbase hydrophobic packing for bonding, several unnatural nucleobases are reported that form selective and stable self-pairs in duplex DNA. These unnatural nucleobases should make it possible to increase the stringency and information content of hybridization or encoding experiments.