Efforts toward expansion of the genetic alphabet: optimization of interbase hydrophobic interactions

Y. Wu, A.K. Ogawa, M. Berger, D.L. McMinn, P.G. Schultz, F.E. Romesberg, J. Am. Chem. Soc. (2000) 122(32):7621-7632.
pubpic2000wuWe characterize six novel unnatural nucleobases – derivatives of the hydrophobic base pair between 7-azaindole (7AI) and isocarbostyril (ICS). Read more about this work in Science and The New York Times.