Efforts toward expansion of the genetic alphabet: information storage and replication with unnatural hydrophobic base pairs

A.K. Ogawa, Y. Wu, D.L. McMinn, J. Liu, P.G. Schultz, F.E. Romesberg, J. Am. Chem. Soc. (2000) 122(14):3274–3287.
pubpic2000cogawaWe show that the stability and selectivity of unnatural base pairs may be comparable to, or even exceed, that of native pairs and that the unnatural bases are orthogonal to the native bases, with correct pairing being favored by at least an order of magnitude relative to mispairing.